Manyuan Long, Ph.D.

Professor
Department of Ecology and Evolution
University of Chicago

Adjunct Professor (Chang Jiang Adjunct Scholar)
Center for Bioinformatics
Life Science College
Peking University

Contact

E-mail:

Degrees, Qualifications:

• Postdoctoral fellow, July 1 1993 - October 31, 1997, joint appointment, Departments of Molecular and Cellular Biology and Organismic and Evolutionary Biology, laboratories of Walter Gilbert and R. C. Lewontin, Harvard University, Cambridge, MA 02138.
• Ph.D., Genetics, University of California, Davis. Degree received December 12, 1992. Dissertation: The origin and evolutionary mechanisms of new genes. Department of Genetics. Laboratory of Charles Langley.
• M.S., Genetics, University of California, Davis. 1990.
• M.S., B.S., Plant Genetics, 1985, Sichuan Agricultural University, Sichuan, China. Plant Quantitative Genetics Institute led by Prof. Zhiren Gao with Profs/ Rong Tingzhao and Ming Daoxu.
• Postdoctoral research associate, Department of Molecular and Cellular Biology (Walter Gilbert's laboratory) and Department of Organismic and Evolutionary Biology (R.C. Lewontin's laboratory), Harvard University, July 1993 - October 31, 1997.
• Residential scholar, Harvard University. Advised undergraduate students in various academic issues. 1994 - 1995 academic year. Supervised undergraduate thesis research in Walter Gilbert's lab, April 20, 1994 - August 30, 1996.
• Research Assistant, Department of Genetics and Center for Population Biology, UC Davis, 1988--1992.
• Teaching Associate, Principles of Genetics, UC Davis, 1989--1992

Previous Experience

• Associate Professor with tenure, Department of Ecology and Evolution, Committees on Genetics and Evolutionary Biology, and The College, The University of Chicago. July 1, 2003 - December 31, 2004.
• Assistant professor, Department of Ecology and Evolution, Committees on Genetics and Evolutionary Biology, and The College, The University of Chicago. November 1, 1997 - June 30, 2003.
• Postdoctoral research associate, Department of Molecular and Cellular Biology (Walter Gilbert's laboratory) and Department of Organismic and Evolutionary Biology (R.C. Lewontin's laboratory), Harvard University, July 1993 - October 31, 1997.
• Residential scholar, Harvard University. Advised undergraduate students in various academic issues. 1994 - 1995 academic year. Supervised undergraduate thesis research in Walter Gilbert's lab, April 20, 1994 - August 30, 1996.
• Research Assistant, Department of Genetics and Center for Population Biology, UC Davis, 1988 - 1992.
• Teaching Associate, Principles of Genetics, UC Davis, 1989 - 1992

HONORS

• National Science Foundation (NSF) CAREER award, 2003-2008.
• David and Lucile Packard Fellowship for Science and Engineering, 1998-2003.
• Allen G. Marr Prize for the Best Ph.D. Dissertation of University of California, Davis, 1993.
• Invited to participate in the 11th Frontier of Sciences Symposium of National Science Academy USA for young scientists.
• Joint / visiting professors or academic advisory councils in other universities/institutes.

Publications

• Zhang J, Dean AM, Brunet F, Long M. Evolving protein functional diversity in new genes of Drosophila. Proc Natl Acad Sci U S A 101(46): 16246-50 [PubMed]
• Wang W, Yu H, Long M. Duplication-degeneration as a mechanism of gene fission and the origin of new genes in Drosophila species. Nat Genet 36(5): 523-7 [PubMed]
• Hillier LW, Miller W, Birney E, Warren W, Hardison RC, Ponting CP, Bork P, Burt DW, Groenen MA, Delany ME, Dodgson JB, Chinwalla AT, Cliften PF, Clifton SW, Delehaunty KD, Fronick C, Fulton RS, Graves TA, Kremitzki C, Layman D, Magrini V, McPherson JD, Mi. Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution. Nature 432(7018): 695-716 [PubMed]
• Long M, Betran E, Thornton K, Wang W. The origin of new genes: glimpses from the young and old. Nat Rev Genet 4(11): 865-75 [PubMed]
• Betran E, Thornton K, Long M. Retroposed new genes out of the X in Drosophila. Genome Res 12(12): 1854-9 [PubMed]
• Wang W, Thornton K, Berry A, Long M. Nucleotide variation along the Drosophila melanogaster fourth chromosome. Science 295(5552): 134-7 [PubMed]
• Wang W, Brunet FG, Nevo E, Long M. Origin of sphinx, a young chimeric RNA gene in Drosophila melanogaster. Proc Natl Acad Sci U S A 99(7): 4448-53 [PubMed]
• Caceres M, Ranz JM, Barbadilla A, Long M, Ruiz A. Generation of a widespread Drosophila inversion by a transposable element. Science 285(5426): 415-8 [PubMed]
• Long M, de Souza SJ, Rosenberg C, Gilbert W. Relationship between "proto-splice sites" and intron phases: evidence from dicodon analysis. Proc Natl Acad Sci U S A 95(1): 219-23 [PubMed]
• Long M, de Souza SJ, Gilbert W. The yeast splice site revisited: new exon consensus from genomic analysis. Cell 91(6): 739-40 [PubMed]
• Long M, de Souza SJ, Gilbert W. Delta-interacting protein A and the origin of hepatitis delta antigen. Science 276(5313): 824-5 [PubMed]
• Long M, de Souza SJ, Rosenberg C, Gilbert W. Exon shuffling and the origin of the mitochondrial targeting function in plant cytochrome c1 precursor. Proc Natl Acad Sci U S A 93(15): 7727-31 [PubMed]
• de Souza SJ, Long M, Schoenbach L, Roy SW, Gilbert W. Intron positions correlate with module boundaries in ancient proteins. Proc Natl Acad Sci U S A 93(25): 14632-6 [PubMed]
• Long M, Rosenberg C, Gilbert W. Intron phase correlations and the evolution of the intron/exon structure of genes. Proc Natl Acad Sci U S A 92(26): 12495-9 [PubMed]
• Long M, Langley CH. Natural selection and the origin of jingwei, a chimeric processed functional gene in Drosophila. Science 260(5104): 91-5 [PubMed]
• Long M. Evolution of novel genes. Curr Opin Genet Dev 11(6): 673-80 [PubMed]
• Long M, Thornton K. Gene duplication and evolution. Science 293(5535): 1551 [PubMed]
• de Souza SJ, Long M, Klein RJ, Roy S, Lin S, Gilbert W. Toward a resolution of the introns early/late debate: only phase zero introns are correlated with the structure of ancient proteins. Proc Natl Acad Sci U S A 95(9): 5094-9 [PubMed]