Hong Qu, Ph.D.

Associate Professor
Center for Bioinformatics
Life Science College
Peking University

Contact

E-mail:
Tel: +86 10 6275 5206
Fax: +86 10 6275 1861

Address

Room 602
New Life Science Building
Peking University
Beijing, P. R. China,
100871

Degrees, Qualifications:

• 9/1993-9/1996 Eng.D. in Applied Chemistry. Beijing Institute of Technology, P.R.China
• 9/1990-7/1993 M.S. in Physical Chemistry. Jilin University, P.R.China
• 9/1986-7/1990 B.S. in Organic Chemistry. Liaoning University, P.R.China

Working Experience

• Teaching undergraduate course on Biology Statistics and Computational Basis et al.
• 11/1998-present Associate professor, Peking University, P.R.China
• 10/1996-10/1998 Postdoctoral Research Fellow, Institute of Pharmacology and Toxicology, P.R.China

Research Interests

• Bioinformatic methods and applications in proteomics
• Computer simulation analysis of macromolecule structures and functions
• Computational Chemistry

Publications

• Yong-Kang Yang, Hong Qu, Dong Gao, Wei Di, Hai-Wei Chen, Xin Guo, Zhong-He Zhai, and Dan-Ying Chen, ARF-like Protein 16 (ARL16) Inhibits RIG-I by Binding with Its C-terminal Domain in a GTP-dependent Manner, J. Biol. Chem. 2011 286: 10568-10580
• Min Zhao, YanMing Chen, DaCheng Qu and Hong Qu*.TSdb: A database of transporter substrates linking metabolic pathways and transporter systems on a genome scale via their shared substrates.2011, 54(1), 60-64
• Zhicheng Lin, Juan J. Canales, Throstur Bjorgvinsson, Morgane Thomsen, Hong Qu, Qing-Rong Liu, Gonzalo E. Torres, and S. Barak Caine, Monoamine Transporters: Vulnerable and Vital Doorkeepers. In Shafiqur Rahman, editor: Progress in Molecular Biology and Translational Science, Vol. 98, Burlington: Academic Press, 2011, pp. 1-46
• Min Zhao and Hong Qu*, PathLocdb: a comprehensive database for subcellular localization of metabolic pathway and its application for multiple localization analysis.BMC Genomics ,2010 (11) (Suppl 4): S13
• Beihai Jiang, Tingting Ren, Bin Dong, Like Qu, Genglin Jin, Jianning Li,Hong Qu, Lin Meng, Caiyun Liu, Jian Wu and Chengchao Shou. Peptide Mimic Isolated by Autoantibody Reveals Human Arrest Defective 1 Overexpression Is Associated with Poor Prognosis for Colon Cancer Patients, American Journal of Pathology. 2010; 177: 1095-1103
• Zhao, M. and Qu, H* Human liver rate-limiting enzymes influence metabolic flux via branch points and inhibitors, BMC Genomics, 2009 (10) (Suppl 3): S31
• S. Song, D. Han, H. Qu, Y. Gong, H. Wu, X. Zhang, N. Zhong and H. Feng , EDA gene mutations underlie non-syndromic oligodontia, J DENT RES.2009; 88: 126-131
• Dong Han, Yu Gong, Hua Wu, Xiaoxia Zhang, Ming Yan, Xiaozhu Wang, Hong Qu, Hailan Feng and Shujuan Song, Novel EDA mutation resulting in X-linked non-syndromic hypodontia and the pattern of EDA-associated isolated tooth agenesis, European Journal of Medical Genetics, 2008, 51(6): 536-546
• Bingjun Jiang,Hong Qu, Yuanlei Hu, Ting Ni, Zhongping Lin, Computational analysis of the relationship between allergenicity and digestibility of allergenic proteins in simulated gastric fluid, BMC Bioinformatics 2007, 8:375
• Feng Cui, Hong Qu, Jian Cong, Xiao-Li Liu, and Chuan-Ling Qiao , Do mosquitoes acquire organophosphate resistance by functional changes in carboxylesterases?, FASEB J..2007; 0: fj.07-8237comv1
• Hong Jiang, Chao Yang, Hong Qu, Zheng Liu, Q. S. Fu, and Chuanling Qiao, Cloning of a Novel Aldo-Keto Reductase Gene from Klebsiella sp. Strain F51-1-2 and Its Functional Expression in Escherichia coli, Appl. Environ. Microbiol., 2007, 73(15):4959-65
• Qun Bi, Xue Zhou, Xiaodong Cen, Hong Qu, Jingchu Luo, Yixiu Huang and Shenggeng Zhu , Efficient targeted anticoagulant with active RGD motif , Thromb Res., 2007;120(4):541-7
• Xiaobo Lei, Yingyu Chen, Guanhua Du, Wenyu Yu, Xiaohui Wang, Hong Qu, Bin Xia, Hongping He, Jianhua Mao, Weixing Zong, Xudong Liao, Maryam Mehrpour, Xiaojiang Hao and Quan Chen, Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2., FASEB J. 2006 Oct;20(12):2147-9
• Beihai Jiang, Wenbin Liu, Hong Qu, Lin Meng, Shumei Song, Tao Ouyang, and Chengchao Shou, A Novel Peptide Isolated from a Phage Display Peptide Library with Trastuzumab Can Mimic Antigen Epitope of HER-2, J. Biol. Chem., Feb 2005; 280: 4656 - 4662
• D.L.You, H. Qu, Q.Chen, Y.Xing, X.C.Gu, M.Luo, Cloning,Expression and Characterization of the Hypoxanthine-Guanine Phosphoribosyltransferase Mutants from Thermoanaerobacter Tengcongensis, Acta Biochim Biophys Sin, 2003,35(9):853-858
• M. Luo, Z.Y. Mi, H. Qu, et al. Cloning and structure analysis of osRACB gene of Rac family, Science in China(Series C), 2003, 33(3):202-214
• Y.Z. Xu, Z.Y. Mi, H. Qu, R.L.You, N.H. Wu, Biochemical characterization of the protein encoded by rice osRACD gene, PROGRESS IN NATURAL SCIENCE, 2004, 14 (4): 332-337
• J.J. Zhou, H. Qu, et al. cDNA cloning,sequence analysis, expression and protein structure modeling of HLA-G1 from Chinese, Acta Scientiarum Naturalium University Pekinensis, 2002, 38(2):212-220
• Y.H. Su, H. Qu, et al, The toxicity test and hypothetical model of bacillus thuringiensis Cry1Aa Helix4, Science in China((Series C), 2002, 45(6):561-568
• J.M. Wang, J.C. Luo, Y. Li, H. Qu, et al, Construction of ice dwarf virus genome database, Acta Microbiologica Sinica, 2001, 41(1):43-48
• Y.F. Ren, H. Qu, et al, Study on the active site of human interleukin-6 receptor, Chinese Science Bulletin, 2000?45(3):301-306
• Y.F. Ren, J.N. Feng, H. Qu, et al, Relationship study on the 3d structure and function of the active site of human interleukin-6 receptor, Science in China((Series C), 2002, 30(2):219-224
• Y.F. Ren, J.N. Feng, H. Qu, et al, The effects of double-site mutagenesis of WSEWS in human IL-6 receptor on the space conformation of the special site of the ligand-bingding domain in the receptor, Academic Periodical Abstracts Of China, 1999, 5(6):749-750
• Y.F. Ren, H. Qu, et al, Homology modeling of the three-dimentional conformation of the ligand-binding area of human interleukin-6 receptor and its disulfide bonds, Academic Periodical Abstracts Of China, 1999, 5(6):746-748
• H. Qu, K.F. Jiao, Computer simulation of the interaction of four isomers of soman on acetylcholinesterase, Chinese Journal Pharmacology and Toxicology, 1999, 13(3):231-236
• H. Xu, F.Y. Li, X.Z. Xu, H. Qu, et al. Theoretical study on the geometry and properties of tran-N-(oxabutyl-2-ene acid) -2,3-benzo-10-aza-1,4,7,13-tetraoxa-cyclopentadeca-2-ene, Acta Chimica Sinica, 1999, 57:345-352
• K.F. Jiao, W.Z. Chen, H. Qu, The Science progress of carbohydrates and life science, Da Xue Hua Xue, 1999,14(1),28-31
• K.F. Jiao, H. Qu, et al. Studies on interaction of AchE with its substrates by computer simulation, Bull Acad Mil Med Sci, 1998, 22(3):195-202
• Qu Hong, Li Qianshu and Zhu Hesun, Quantum Chemistry Study on N12, Chinese Science Bulletin, 1997, 42(6):462-465
• Li Song ,Qu Hong and Li Qianshu, Quantum Chemical Study on N60, Chemical Journal of Chinese Universities, 1997, 18(2):297-299
• Li Qianshu, Hu Xuguang and Qu Hong, INDO and Localized Molecular Orbitals Study on the Structures of Cr2(O2CR)4L2 Complexes, Chemical Journal of Chinese Universities, 1997, 18(4):590-594
• Li Qianshu, Qu Hong and Zhu Hesun, Quantum Chemistry Calculations of Nitrogen Cages N10, Chinese Science Bulletin, 1996, 41(14):1184-1188
• Fu Qinghong, Qu Hong et. al., Synthesis, Crystal Structure and Property of [Mo(dtc)4][Nd(dtc)4] Complex, Zhongguo Xitu Xuebao, 1995, 13(2):174-176